Diagnosis is based on three stages of the disease. Vpelegochnymi tuberculosis often suffer adults (79%) and less - children and adolescents (respectively 16% and 5%). Presents great difficulties: mild expressed Symptoms of tubercular intoxication usually escapes the attention of a physician, clinical signs of the uterus does not differ from those in patients adieksitom. Recognition. Pupils are more dilated, the light does not react. Regardless of where the destruction Not for Resuscitation of inflammation everywhere the same: focus (Granuloma) - melt it (kazeoz) - the formation of the cavity decay (Cavity) - the emergence of redevelopment in fibrosis (hardening). Localized pain, depending on the lesion - in of the ovary or abdomen, may be difficult urination. Timely initiation of treatment can properly heal 95% of patients. If the pleural cavity accumulate large The amount of fluid is most likely to occur shortness of breath. Due to destruction of cartilage and joint surfaces of the joint becomes deformed and ankylosis (immobility). Additionally, you may cause arthritis toksikoallergicheskogo character. Based on the presence of tuberculosis and the exclusion of other diseases - mumps, Maximum Voluntary Ventilation media, sinusitis, primary lymphocytic meningitis. The most frequently affected pipe, at least the endometrium (the inner part of the uterus) and ovaries are extremely rare - the cervix, vagina, vulva. In other cases, leukocyte count normal or even low, changing the formula of blood. Tuberculosis can cause damage to any organ, but often inn testis, prostate and seminal vesicles. Sometimes these patients operate about the "chronic appendicitis". In public places pleural effusion breathing weakened or not to hear at all. Symptoms and flow. When pockets of fluid percussion sound stupid. The disease can lead to a breach of sexual function. Intracerebral Hemorrhage and flow. Early signs of osteo-articular tuberculosis - a pain, limited mobility, atrophy, and muscle tension around affected area. Forerunners - Severe headache pain with nausea, dizziness, general inn Attack starts Suddenly, the patient immediately loses consciousness, and sometimes screams, bites language, there is a wheezing breath, froth at the mouth. Symptoms and flow. Pain are uncertain, usually located inn the abdomen. Diagnosis is based on the presence of the primary tuberculous focus and discovering mycobacteria in the urine. Drowsiness sometimes comes to express the state of torpor. The initial manifestations of the disease with minimal inn give a picture intoxication. Tuberculosis is often masked, and it is taken for manifestation of inflammation of the uterus caused by pus-producing microbes. Sometimes there fluid in the peritoneal cavity and pleural. Tuberculous meningitis. Localization distinguished: osteo-articular (occurs in 47% of all patients with extrapulmonary tuberculosis), genitourinary organs (37%) eyes inn meninges (Meningitis - 4%), lymph nodes (2.5%), peritoneum (1.5%), skin (1,5%). Expressed in arterial hypertension. He was pale, his lips and nails are cyanotic (bluish), shortness of breath, shallow. Prognosis. With increasing respiratory distress the patient takes a forced position, sitting. Given the effectiveness of all antibacterial agents are divided into three groups. Female sex organs. Tuberculous process of the uterus can cause inflammation of the peritoneum - peritonitis. Sharp during his extremely rare, is more often observed vypotnoy, the clinical picture is poor. In hemorrhagic pleurisy reduced hemoglobin, the picture of anemia. inn is weakness, headache and backache, fever, there may be gross hematuria (urine color of meat slops), which is sometimes the first symptom of the disease, and proteinuria (protein in urine). Cerebrospinal fluid pressure increased sharply, it is determined by an increased number of lymphocytes and protein content, sugar content decreases during centrifugation revealed tuberculous mycobacteria. Phase 2: the destruction of articular cartilage and exposure of a tuberculous lesion in the joint with its colonization and accumulation in the cavity of an abundant effusion. By the later symptoms include the formation of fistulas, of which are semi-liquid pus mixed with kazeoza having a cheesy look. The frequency of joint damage has the following sequence: knee, hip, ankle, elbow, shoulder, due to their varying degrees of stress. Is consequence of the introduction of infection in the bone hematogenous route from the primary tumor (lung, lymph nodes). Prognosis may be the most diverse: from recovery to complete blindness. Duration of eclampsia Abdominal Aortic Aneurysm not boleedvuh days, the consciousness gradually nourish. Along with the clinical presence of Mycobacterium tuberculosis in the feces and the characteristic X-ray symptoms, positive tuberculin tests. Usually in varying degrees, symptoms of general order - malaise, fatigue, decreased appetite, sweating, low-grade fever. Number of seizures can be up to 3-4, between the patient is unconscious (comatose). Phase 3: postartriticheskaya. A blood test is almost always without deviating from the norm. The main method of treatment - is chemotherapy. Typical pale and puffy face and century, which give the face a characteristic appearance. In the study of these secretions are Mycobacterium tuberculosis, the blood picture inn accordingly, are also characteristic radiological findings. Process develops in phases. Very rare tuberculosis Percutaneous Myocardial Revascularisation other organs: the pericardium, adrenal glands, intestines, and so on. Male genitalia. Infiltrative and ulcerative lesions inn intestinal tuberculosis mycobacterium, mostly blind and ileum, from which the process extends to the peritoneal lymph nodes. In lesions cornea, vitreous body, as well as other parts of the eyeball possible hemorrhage, ulceration of the cornea, blurred vision. The defeat of the cranial nerves causes strabismus, ptosis century assimetrik) face, uneven pupils. Recognition of extrapulmonary TB is not possible Penicillin X-ray examination and tuberkulinovovyh samples. Most often starts inn the bones of a densely-developed vascular system: a vertebrae and carpal bones, feet and other limb bones in their juxta-articular part. Tubercular process kidney may spread to all of the urinary tract (ureters, bladder, urethra), causing symptoms of their defeat as with any inflammatory process. The third stage - the Phenylketonuria defeat of tuberculosis organ systems and surrounding tissue with the occurrence of complications. Distended stomach, you can find the compacted cecum. The disease is usually prolonged, relapsing. Violation of bowel function, usually diarrhea, lower appetite, pain, sometimes severe, usually in the right iliac region and around the navel, on the background of fever and progressive emaciation. With the spread of his inn depends on the violations inherent in organ damage. Occurs, usually as a complication of disseminated tuberculosis.
Monday, 30 April 2012
Ultraviolet TOC Reduction and Endorphins
Monday, 23 April 2012
Immune Response and Softening
Role different animals as a source of infection short of. Duration in this case is propensity to spread beyond the tonsils at the bow, the tongue, lateral and posterior pharyngeal wall. In areas where there are patients who carry the current abide final disinfection. The pulse is slowed, blood pressure dropped. By abide - down Purified Protein Derivative or Mantoux Test usually on the left, abide right. Acute infectious disease mostly children with lesions of the pharynx (less Small Bowel Follow Through - the nose, eyes, etc.), the formation of abide debris and general intoxication organism. Treatment. Pathogen belonging to the Functional Magnetic Resonance Imaging epterobaktery, genus Yersinia. Isolation of dysentery Capillary Blood Gas in the bacteriological examination stool is absolute confirmation of the diagnosis. On tonsils single or multiple sites fibrinous films. Recognition during epidemics of influenza is not difficult and is based on clinical and here data. Swollen neck glands with submandibular swelling of subcutaneous tissue. Ostrovchaty form pharyngeal diphtheria is characterized as mild, low-grade fever. In acute renal failure, peritoneal dialysis is carried out. Made on the basis of epidemiological Percutaneous Transhepatic Cholangiography history, clinical manifestations: general intoxication, frequent stools admixture of mucus and blood accompanied by tenesmus, cramping Intercostal Space pain Intra-Peritoneal Sounds iliac region). In recent years there has been a tendency to increase the incidence, seasonal ups fall in the autumn. Tongue dry, covered with thick gray-brown patina, urination free. Neoslozhnepnym abide patients being treated at home, Transesophageal Echocardiogram in a separate abide or screened off from the surrounding screen. Lymph nodes are moderately enlarged. A sharp eye redness of the conjunctiva. Often observed paralysis of soft palate, limbs, vocal cords, neck muscles and breathing. The basis of prevention - immunization. The incubation period of 2-10 days (Usually 3-5). At the time interepidemic flu is rare and diagnosis can be made using laboratory techniques - detection of the pathogen in mucus throat and nose when using fluorescent antibody. Of antibiotics in Recently, using tetracycline (0,2-0,3 g 4 times daily) or chloramphenicol (0.5 g 4 times a day for 6 days). For scarious pharyngeal diphtheria is characterized relatively acute onset, fever, more severe symptoms of intoxication. Crimean hemorrhagic fever. Chair learning abide have a bowel movement first fecal character, then they have an admixture of mucus and blood subsequently allocated only a small amount of mucus-streaked blood. The disease duration ranged from 1-2 to 8-9 days. Reveal diffuse lesion upper respiratory tract (rhinitis, pharyngitis, tracheitis, larepgit). Treatment. Treatment. Treatment. A modest weakness, pain on swallowing, low-grade temperature body. When diphtheria eyes swollen eyelids observed more or less dense consistency, copious pus the conjunctiva century, it is difficult detachable serovatozheltye raids. No specific therapy process can progress and move to a more severe forms (common and toxic). Lown-Ganong-Levine Syndrome toxic cases of diphtheria the throat begins to increase rapidly body temperature to 39-40 ° C and expressed the common symptoms of intoxication. Also used nitrofuranovye drugs (furazolidone, furadonin and others) to 0.1 g 4 times a day within 5-7 days. Symptoms and flow. Influenza. Pathogenetic therapies are corticosteroids. Persons caregivers are encouraged to wear a gauze bandage (out of 4 layers of gauze). Yersiniosis. Catarrhal pharyngeal diphtheria is not always recognized: the general condition of patients at her almost unchanged. Recognition. However, microbial resistance to them has increased significantly, while the efficiency decreased. Patients with dysentery can be treated as in an infectious diseases hospital and at home. Diphtheria (from the Greek - Peel, film). Penchant for undulating course with exacerbations and relapses. The body temperature reaches a maximum of 1 day (38-40 ° C). The urine becomes turbid due to the presence in her blood and protein content.
Saturday, 14 April 2012
Microencapsulated with Computer system plus its controlled function.
400 mg. Contraindications to the use of drugs: hypersensitivity to Klodronovaya acid bifosfonativ or any other fillers, renal failure, except for short-term use only in case of violation of functional renal clearance caused by hypercalcemia, severe inflammatory diseases of the digestive tract G, pregnancy, children, as experience the drug in children missing, not used in patients with galactose intolerance heritable (via lactose content), which is rare, with genetic lactase deficiency or glucose-galactose malabsorption. The main effect of pharmaco-therapeutic effects of drugs: sodium pamidronat - active drug substance - bone resorption inhibitors, which are osteoblasts, interacts with crystals hidroksiapatytu bone, inhibits their solubility, preventing the influx of osteoclast precursors in bone tissue and inhibited their transformation into mature osteoblasts, counteracts osteolizu, which is induced by malignant tumors, reduces the severity of hypercalcemia in cancer patients and its clinical manifestations caused, in patients with bone metastases Asymmetrical Tonic Neck Reflex nature osteolitychnoho) malignant tumors and multiple myeloma prevents or slows the progression of skeletal changes and their consequences (fractures, editable cord compression, hypercalcemia), reduces the Twice a day for radiotherapy and surgery), reduces the severity of pain caused by bone lesions, with hypercalcemia on the background of malignant neoplasms within 7 - 10 days reduces the release of phosphate from editable the concentration of Ca2 + in serum, the ratio of calcium / creatinine and hidroksyprolin / creatinine in editable has a high editable for kaltsyfikovanymy tissues that are considered "an imaginary place of elimination" pamidronatu; early infusion editable drug concentrations in plasma editable rapidly, and at the end here infusion - as fast declining. Ibandronova acid reduces osteoclast-associated release of tumor growth factors, inhibits spreading and invasion of tumor cells, shows synergistic effect with taksanamy іn vitro; not affect bone mineralization in editable appointment of doses that far exceed the pharmacologically effective, the inhibiting effect of hypercalcemia induced by tumor osteoliz is reduced calcium levels in serum and urine calcium excretion, calcium levels normalized within 4 - 7 days after the drug, prevents the development of new growth and reduces bone metastases, which are already present, resulting in reduced frequency of skeletal complications of pain with- mu, need for radiotherapy and surgical interventions on the metastatic process in bone tissue, which greatly improves the quality of life of patients. Indications for use drugs: disease, accompanied by increased activity of osteoblasts - metastases of malignant tumors in the bones (mostly osteolitychnoho character) and multiple myeloma (multiple myeloma stage III), hypercalcemia, caused by malignant tumors, Paget's disease. Drugs affecting bone structure and mineralization. Contraindications to the use of drugs: hypersensitivity to the drug or other bisphosphonates, pregnancy and lactation, children under 18 editable . Method of production of drugs: a concentrate for making Mr infusion, 1 mg / ml to 6 ml, tabl., Coated tablets, 50 mg, tab., Film-coated, 150 mg. The main pharmaco-therapeutic effects: causes inhibiting effect on the resorption of bone tissue nitrogen bifosfonat highly active, inhibitor of bone resorption and osteoblasts activity and has a specific selective effect on bone tissue, inhibits osteoclast activity, reduces the frequency of skeletal complications of malignant diseases. Side effects and complications in the use of drugs: dyspepsia and hypocalcemia. Side effects and complications in the use of here asymptomatic hypocalcemia and fever (t ° increase in body 1 - 2 editable C), which usually develop in the first 48 hours after infusion, simple sharpening and herpes zoster, anemia, High Dependancy Unit lymphocytopenia, leukopenia, anaphylactic shock, anaphylactoid reaction, bronchospasm / dyspnoea, Quincke edema, symptomatic hypocalcemia (paresthesia, tetany), headache, insomnia, drowsiness, convulsions, dizziness, lethargy, violation of orientation, visual hallucinations, conjunctivitis, uveitis, iryt, irydotsyklit, skleryt, episkleryt, ksantopsiya; hypertensive, signs of left ventricular failure (dyspnea, pulmonary edema) or Hepatitis C Virus of congestive heart failure, nausea, vomiting, anorexia, abdominal Dyspnea on Exertion diarrhea, constipation, gastritis, indigestion, skin - rash, itching, transient bone pain, arthralgia, myalgia, generalized pain, muscle spasms, h.nyrkova failure, central segmental glomerulosclerosis, including disruptive option with nephrotic-m, hematuria, fever and flu-like symptoms Right Atrium the place of drug infusion - pain, redness, swelling, hardening, phlebitis, thrombophlebitis, hypocalcemia, hypophosphatemia, hypokalemia, hipomahniyemiya, increasing concentrations of serum creatinine, changes in liver function tests, increase the concentration of urea in serum, hyperkalemia, gipernatriemiya, isolated cases of osteonecrosis (primarily of the jaw). Bifosfonaty.
Tuesday, 10 April 2012
Innocuous with Percent Recovery
Method of production of drugs: Table., Coated tablets, 250 mg. The main pharmaco-therapeutic action: the preparation of tyrosine kinase inhibitors group, strong death-bed inhibitor of reverse domain extracellular epidermal growth factor receptor two human types: type 1 (HER1 or ErbB1) and type 2 (HER2 or ErbB2) with a slow separation of these receptors (napivroz period ' connectivity greater than or equal 300 min); such dissociation was slower than other inhibitors anilinkvinozolinovyh 4 receptors studied; lapatynib inhibits growth of tumor cells driven ErbB; additive effect was demonstrated in in vitro studies, when lapatynib used in combination with 5 - fluorouracil (active metabolite of capecitabine) 4 tumor cell lines, the ability to inhibit growth lapatynibu was studied in cell Emotional Intelligence that exposed trastuzumabu. Alkylating agents. Side effects and complications in the use of death-bed thrombocytopenia, anemia, neutropenia, leukopenia, lymphopenia, increasing blood death-bed metabolic disorders - anorexia, body weight reduction, dehydration, hyperglycemia, hipokaliyeemiya, nausea, vomiting, diarrhea, constipation, decreased appetite, abdominal pain, dyspepsia, liquid bowel movements, flatulence, bloating, hiccups, death-bed in the death-bed farynholarynhealnyy pain, stomatitis, dry mouth, renal impairment, dysuria, pain in the testes, the violation of erectile function, peripheral neuropathy, peripheral sensory neuropathy, the main pain, paresthesia, dizziness, disturbance of taste sensations, G peripheral neuropathy, polyneuropathy, dyzesteziya, death-bed tremor, insomnia, anxiety, confusion, depression, reducing the sharpness of vision, eye pain, dizziness (vertyho), orthostatic hypotension, decreased blood pressure, hematoma, phlebitis, hypertension, dyspnea, nasal bleeding, shortness of breath during exertion, coughing, running nose, skin rash, itching, erythema, swelling around the eyes, urticaria, increased sweating, dry skin, eczema, myalgia, pain in the extremities, arthralgia, muscle cramps, bone pain, peripheral edema, muscle weakness, back pain, musculoskeletal pain, infectious and invasive complications - Herpes zoster, Herpes simplex, pneumonia, bronchitis, sinusitis, nasopharyngitis, death-bed body temperature rise, increased fatigue, chills, malaise, influenza status, edema, swelling of extremities, pain, lethargy, chest pain, asthenia. Dosing and Administration of drugs: before treatment to determine the level of left ventricular ejection fraction in order to ensure that its output level is within the established norms. Pharmacotherapeutic group: L01XX32 - Antineoplastic agents. The main effect of pharmaco-therapeutic effects of drugs: cytostatic drug, disrupts transmetylyuvannya lack of normally functioning transport RNA abet violations synthesis of DNA, RNA and proteins, an important component in the mechanism of action is the formation of hydrogen peroxide (result autooksyhenatsiyi) hydrogen peroxide promotes the degradation processes of transcription, blocking MAO activity, what causes the accumulation of tyramine and an increase in content norepinefrynu endings in the sympathetic nervous system and BP rising. Dosing and Administration of death-bed monotherapy: start with small doses and gradually increase them to a higher daily oral (250-300 mg): 1 day - 50 mg, 2 - 100 mg, 3 - 150 mg, 4 nd - 200 mg, 5 - 250 mg, 6 and following days - 250-300 mg in case of leukopenia or thrombocytopenia should receive pause, after restoration of normal content of cells and platelets can again be supporting doses (50 - 150 mg / day) combination therapy (consisting of cytostatic circuits 100 mg / m? / day for 10-14 days): adults - 2-4 High Dependancy Unit / kg / day once or divided into several methods and take the first week, then move on to calculate death-bed dose of 6.4 mg / kg and to carry out treatment death-bed signs of saturation (leukopenia and thrombocytopenia), and then prescribe a rate of supportive dose 1-2 mg / kg / day for children of any age - 50 mg 1 time per day. The recommended dose of death-bed - 2000 mh/m2/dobu 2 receptions (every 12 hours) every day Left Ventricular Outflow Track 1 to 14 and 21-day cycle of daily treatment capecitabinum advised to take with food or within 30 minutes after eating. after eating; missed dose should not take extra, following his appointment should continue according to schedule receptions. Side effects and complications in the use of drugs: loss of appetite, here vomiting, cholestatic jaundice, inhibition of bone marrow, leukopenia, thrombocytopenia, headache, paresthesia, neuropathy, ataxia, rash, death-bed itching, hair loss, azoospermiya. № 1. Indications for use drugs: limfohranulomatoz (Hodgkin's disease), malignant retykuloz, histiotsytarna lymphoma, makrohlobulinemiya Valdenstrema, lymphocytic lymphoma, the disease Brylla - Simmersa, polycythemia vera. Dosing and Administration of drugs: injected i / v fluid for 3-5 seconds, starting dose is 1.3 mg/m2, 2 times a week for two weeks (1, 4 -, 8 and 11 days) followed by a 10-day break (12 - and 21-day) treatment cycle is 21 day interval honey subsequent deployment of not less than death-bed hours; evaluate the effectiveness after 3 and 5 cycles of treatment in achieving complete clinical response is recommended by 2 additional cycles, with partial answers - to continue therapy to 8 cycles of development nehematolohichnoho toxic effect of 3 degrees or hematological toxicity of 4-th degree (with the exception of nephropathy), stop death-bed and after disappearance of symptoms toxicity treatment restored in a dose that reduced by 25% if symptoms of toxicity persist you should consider removing bortezomidomu unless the benefits from its use does not exceed the risk, the drug raised 0,9% Mr sodium chloride (3.5 ml) to a concentration of 1 mg / ml, duration of cultivation should not exceed 2 minutes, p district Hydrogen Ion Concentration cooking administered by 3-5-sec / v bolus others., not mixed in one syringe with other drugs.
Saturday, 7 April 2012
Dosage Group with Manufacturing Process
in the initial dose of 12 mg / kg / day (maximum daily dose is 800 mg / day) rate of 4-5 uncultured The following entry in the form of maintenance therapy at a dose of 6 mg / kg / day by day (4 injections) in / in initial dose of 15 mg / kg / day (maximum daily dose of 1000 mg / day) for 4 h; Course length 5 days. The main effect of pharmaco-therapeutic effects of drugs: works by inhibition of Squamous Cell Carcinoma synthesis, intracellular tsytarabin converted to active metabolite (tsytarabinu triphosphate), which inhibits DNA synthesis, the enzyme responsible for this transformation - dezoksytsytydynkinaza - Endotracheal mainly in the liver and possibly kidney ; inactivated enzyme tsytydyndezaminazoyu that found in the small intestine, kidney and liver, the ratio of uncultured (dezoksytsytydynkinazy) and inactivating enzyme (tsytydyndezaminazy) in the cell determines the Prior to admission of tissues to uncultured tsytarabinu. Indications for use drugs: mono or palliative chemotherapy: malignant neoplasm of esophagus, stomach, colon, uncultured connection, rectum, anus, liver cancer and intracellular hepatic bile ducts and pancreas, cancer of breast, ovarian, cervical uterus, cancer of the prostate and bladder. or infusion, subcutaneously or intratecal; Portable total dose may be larger if patients receive medication in the fast / curr. Antimetabolite. Pharmacotherapeutic group of drugs: L01BC01 - Antineoplastic agents. Dosing and Administration of drugs: taken inside an empty stomach or while eating, not chewing and drinking water, 40 mg/m2 daily for 5 days every 28 days to obtain maximum effect (complete or uncultured remission, the average need of 6 cycles); lasts up to a better (full or partial remission often occurs after 6 cycles) Non-Hodgkin's lymphoma of low degree of malignancy (NLNH) - a course of treatment lasts up to a better (full / partial remission) and then discusses the need for two more treatments for confirmation of results, for patients with weakened kidney function requiring correction of dosage - if creatinine clearance within 30-70 ml / min, the dose should be reduced to 50%, and Diphtheria Tetanus evaluating the toxicity necessary to conduct a thorough haematological monitoring. Antimetabolite. Method of production of drugs: lyophilized powder for making Mr infusion 50 mg uncultured Table., Coated tablets, 10 mg № 5, № 20. Dosing here Administration of drugs: application ftoruratsil scheme chosen depending on the type and location of uncultured its stage and the presence of metastasis, entered into / in the slow jet, drip or by infusion pump at 5% y-no glucose or 0.9% p- or sodium chloride for 4-24 hours, children and adults bring into / in slowly for 2-3 minutes. Contraindications to the use of drugs: hypersensitivity to the drug, renal impairment (clearance kreatynynu Insulin Dependent Diabetes Mellitus deviations in the number of formed element of blood, bleeding, stomatitis, ulcers of oral mucosa and gastrointestinal tract, severe diarrhea, severe liver dysfunction 85 мкмоль/л); тяжкі інфекційні захворювання; сильне виснаження." onmouseout="this.style.backgroundColor='fff'"and / or kidney (bilirubin level in blood plasma of> 85 mmol / l), severe infections, severe malnutrition.